Endocrine Abstracts

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality possibly due to increased prevalence of main traditional cardiovascular risk factors. It is not clear though whether the incidence of atherosclerosis is truly enhanced. Moreover recent in vitro studies show a protective role of (GH) and IGF1 (insulin-like growth factor-1) on the endothelium. As expression of endothelial regenerative reserve, endothelial progenitor cells (EPCs) could...

There is evidence for a strong association between Cushing’s syndrome, characterized by a cluster of systemic complications, and increased cardiovascular risk. To our knowledge, coronary circulatory function has not been explored in Cushing’s syndrome. The aim of the study was to evaluate coronary flow reserve (CFR), an index of coronary microvascular function, in patients with Cushing’s syndrome. Thirteen newly diagnosed patients with Cushing’s syndrome (1...

Gigantism is an extremely rare condition and hence the relevant literature is largely a series of case reports. We present data on patients with gigantism <20 years of age identified from Pfizer’s Acrostudy registry of patients treated with pegvisomant.Eleven patients (5M) were identified: IGF1 at diagnosis was 1.6×ULN (1.15–3.3), height +5 SDS (1.1–3.8) and age 14.5 years (4–19). The three youngest (4, 7 and 14 years) had pi...